Novel Therapeutic Approaches of Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Current therapeutic approaches to pulmonary arterial hypertension.
Pulmonary hypertension is a heterogeneous hemodynamic and pathophysiological state that is observed in a number of clinical conditions, which have been divided into six diagnostic groups. Although the increase in pulmonary pressure observed in these clinical groups may be similar, underlying disease mechanisms, diagnostic methods, and prognostic and therapeutic consequences are completely diffe...
متن کاملNovel therapeutic perspectives in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) refers to a disease spectrum of the small pulmonary arteries leading to a progressive increase in pulmonary vascular resistance, right ventricular failure and, ultimately, death [1]. It is usually accepted that a vasoconstrictive factor is involved in PAH [2]. However, pure vasodilators, such as calcium channel blockers, have so far provided little or no be...
متن کاملPulmonary arterial hypertension: therapeutic algorithm.
The numerous controlled clinical trials performed recently in pulmonary arterial hypertension (PAH) can allow us to abandon a clinical-based treatment strategy and adopt an evidence-based therapy. The treatment algorithm is restricted to patients in NYHA class III or IV. The different treatments have been evaluated mainly in sporadic, idiopathic PAH and in PAH associated with scleroderma or to ...
متن کاملNovel Approaches to Treat Experimental Pulmonary Arterial Hypertension: A Review
BACKGROUND Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by an increase in pulmonary artery pressure leading to right ventricular (RV) hypertrophy, RV failure, and ultimately death. Current treatments can improve symptoms and reduce severity of the hemodynamic disorder but gradual deterioration in their condition often necessitates a lung transplant. METHOD...
متن کاملTherapeutic Strategies in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare condition; yet this very rarity can be a disadvantage when it comes to treatment, making PAH difficult to diagnose, and resulting in suboptimal patient care. Furthermore, the global burden of PAH remains poorly understood and largely underestimated, as PAH commonly presents as a comorbidity with such conditions as systemic sclerosis, COPD, idiopat...
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ژورنال
عنوان ژورنال: International Journal of Angiology
سال: 2019
ISSN: 1061-1711,1615-5939
DOI: 10.1055/s-0039-1692140